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KMID : 0988920120100040383
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Intestinal Research
2012 Volume.10 No. 4 p.383 ~ p.387
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Drug Rash with Eosinophilia and Systemic Symptoms Syndrome in a Patient on Sulfasalazine for Ulcerative Colitis
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Kang Kyung-Hwan
Lee Chang-Kyun
Kim Hyo-Jong
Shim Jae-Jun
Jang Jae-Young
Dong Seok-Ho
Kim Byung-Ho
Chang Young-Woon
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Abstract
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Drug rash with eosinophilia and systemic symptoms (DRESS) is a life-threatening systemic drug reaction characterized by fever, rash, hematological abnormalities, lymphadenopathy, and multiple internal organ involvement. Unfortunately, a long latency period as well as clinicians’ unawareness of the disease entity often results in a delay of prompt diagnosis and treatment in clinical practice. A search of the literature revealed only few reports on DRESS in patients with inflammatory bowel diseases. The pathogenesis of the disease is not clearly understood, although several possible mechanisms, such as drug detoxification, slow acetylation, and reactivation of human herpes viruses, have been proposed in its development. Here, we present a rare case of DRESS associated with viral reactivation and defects in drug metabolism in a 22-year-old man who had been on sulfasalazine for 6 weeks to treat ulcerative colitis.
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KEYWORD
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Drug Eruptions, Hypersensitivity, Sulfasalazine, Human Herpes Virus, Ulcerative Colitis
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